منابع مشابه
Nanomechanics of Type I Collagen.
Type I collagen is the predominant collagen in mature tendons and ligaments, where it gives them their load-bearing mechanical properties. Fibrils of type I collagen are formed by the packing of polypeptide triple helices. Higher-order structures like fibril bundles and fibers are assembled from fibrils in the presence of other collagenous molecules and noncollagenous molecules. Curiously, howe...
متن کاملHierarchical nanomechanics of collagen microfibrils
Collagen constitutes one third of the human proteome, providing mechanical stability, elasticity and strength to connective tissues. Collagen is also the dominating material in the extracellular matrix (ECM) and is thus crucial for cell differentiation, growth and pathology. However, fundamental questions remain with respect to the origin of the unique mechanical properties of collagenous tissu...
متن کاملPurification of Type I Soluble Collagen
Objective-To study collagenase production in labial salivary glands in patients with Sjogren's syndrome (SS). Methods-Collagenases were localised in labial salivary glands by immunohistochemistry. Collagenase activity against triple helical type I collagen monomers in stimulated saliva was measured using sodium dodecyl sulphate polyacrylamide gel electrophoresis and laser densitometry; tissue i...
متن کاملAnalysis of Type I Collagen Products
Advanced BioMatrix offers a large number of extracellular matrix (ECM) and three dimensional (3D) scaffold products with one of the most extensive Type I collagen product offerings (see Exhibit 1). One analytical method for evaluating the quality, purity and consistency of the products is Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS PAGE electrophoresis). The purpose of the do...
متن کاملRegulation of type I collagen genes expression.
Type I collagen, the most abundant protein of the body, is preferentially synthesized in bone, dermis, and tendons by two cell types, the osteoblast and the fibroblast. The expression of type I collagen is increased in the various forms of fibrosis such as lung, liver, bone marrow fibrosis and scleroderma. Type I collagen is a heterotrimer molecule consisting of two alpha 1(I) chains and one al...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2016
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.05.038